Product Details

Alprazolam (Xanax) is a fast-acting benzodiazepine. It relaxes your emotions and muscles by affecting chemicals in the brain.

Alprazolam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that it works by enhancing the activity of certain neurotransmitters in the brain.

Alprazolam is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

Are generic versions identical to brand name Xanax?

Generic versions of Xanax cost less but carry the same general benefits and risks. However, they may not be available in all formulations, such as the longer-lasting, sustained-release variety.

Just like the brand-name versions, generic drugs available for prescription are reviewed and approved by the U.S. Food & Drug Administration to ensure they (FDA, 2017):

• Contain the same key (active) ingredients
• Have the same strength and dosage
• Perform the same way in the body

However, the FDA defines “same” as “bioequivalence,” a term that refers to the active ingredient in comparable medications. If a generic drug is bioequivalent, it means that the active ingredient in a generic performs in the same manner to the pioneer drug (FDA, 2007). Here’s the thing: The FDA allows for some wiggle-room for that performance of the active ingredients in a generic drug, meaning its performance has to be “approximately the same”, but doesn’t have to be exactly 100% similar to the active ingredient of the pioneer drug.

What’s more, inactive ingredients in a generic drug are not held to the same standard. “Other characteristics, such as colors and flavorings that do not affect the performance, safety, or effectiveness of the generic medicine may be different,” the FDA states (FDA, 2021). In rare cases, this can present problems. A person could have an allergic reaction to an inactive ingredient in a generic medication that does not exist in the branded version, for example (CHADD, 2017).

So while generic versions of Xanax are supposed to work in the same way and provide the same benefit as the brand-name medicine, there’s a chance that they are not 100% identical.

The important role of generic drugs and the differences

One large study found generic drugs differed by about 3.5% in their absorption into the body compared to their branded counterparts (Davit, 2009). Some generics were absorbed slightly more, some slightly less.

According to the FDA, “this amount of difference is expected and clinically acceptable, whether for one batch of brand-name medicine tested against another batch of the same brand or for a generic tested against a brand-name medicine” (FDA, 2009).

Reassuring as that may be, a given generic version of Adderall might slightly differ in terms of bioequivalence and inactive ingredients from the brand–and from each other. Also worth noting: Between one prescription fill and the next, a pharmacy might change the generic variety it sells without notice (CHADD, 2017).

Regardless, some patients and even some healthcare providers might perceive generic drugs as being less effective than the brand-name products they aim to duplicate. So one large independent, non-governmental study of insurance-company records examined outcomes among 3.5 million patients using eight different drugs for various conditions. The research, published in the journal PLoS Medicine, found generics to be just as effective (Desai, 2019).

The upshot: While generic drugs are generally considered safe and effective and are a very important cost-saver for people who need them, they are not 100% identical to brand-name drugs. These differences are not medically important, according to the FDA. Armed with this information, you can still seek lower drug prices, but it’s wise to have a conversation with your healthcare provider about the benefits and risks of Xanax versus a generic and then aim to stick with what works.